Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol

Abstract Background Immediate hypersensitivity reaction to ursodiol is rare and there no previously published protocol on desensitization. Case presentation A 59-year-old woman with primary biliary cholangitis (PBC) developed an immediate ursodiol—the first-line treatment for PBC. When she switched a second-line treatment, her PBC continued progress. As such, completed novel 12-step desensitization oral ursodiol. She experienced recurrent pruritus after each dose following desensitization, which subsided month of being daily Conclusion uncommon. Our case demonstrated that this could be safely implemented when alternative options are not available or have proven inferior in efficacy.